VARUKORG ( 0 )
Articles in peer-reviewed published journals
(upper respiratory tract infections URTI, fatigue, runny nose, nasal congestion, sore throat, headache, low-grade fever and cough)
Studies show that the cold is shortened, as well as has an expectorant and cough suppressant effect. Also counteracts fatigue and provides faster recovery.
Antitussive effect of a fixed combination of Justicia adhatoda, Echinacea purpurea and Eleutherococcus senticosus extracts in patients with acute upper respiratory tract infection: A comparative, randomized, double-blind, placebo-controlled study. Barth A, Hovhannisyan A, Jamalyan K, Narimanyan K. Phytomedicine. 2015 22(13):1195-1200. doi: 10.1016/j.phymed.2015.10.001. https://pubmed.ncbi.nlm.nih.gov/26598919/
Randomized trial of a fixed combination (Kan Jang) of herbal extracts containing Adhatoda vasica, Echinacea purpurea and Eleutherococcus senticosus in patients with upper respiratory tract infections. Narimanian M, Badalyan M, Panosyan V, Gabrielyan E, Panossian A, Wikman G, Wagner H. Phytomedicine. 2005 12(8): 539–547. DOI: 10.1016/j.phymed.2004.10.001 https://pubmed.ncbi.nlm.nih.gov/16121513/
A controlled clinical study of Kan Jang mixture in the treatment of uncomplicated upper respiratory tract infections. Thom E, Wollan, T. Phytotherapy Research. 1997 11(3): 207-210. https://doi.org/10.1002/(SICI)1099-1573(199705)11:3<207::AID-PTR82>3.0.CO;2-S
(prevents colds, upper respiratory tract infections URTI, fatigue, runny nose, nasal congestion, sore throat, headache, low-grade fever, sinusitis)
Studies show that common cold is prevented and reduction of cold symptoms and sinusitis. The immune-stimulating effect also contributes to the normal function of the airways and the body’s physical well-being. Also counteracts fatigue and provides faster recovery.
Efficacy of Kan Jang® in patients with mild COVID-19: Interim analysis of a randomized, quadruple-blind, placebo-controlled trial. Ratiani L, Pachkoria E, Mamageishvili N, Shengelia R, Hovhannisyan A, Panossian A. Pharmaceuticals 2022, 15, 1013. https://doi.org/10.3390/ph15081013
Comparative controlled study of Andrographis paniculata fixed combination, Kan Jang® and an Echinacea preparation as adjuvant, in the treatment of uncomplicated respiratory disease in children. Spasov AA, Ostrovskij OV, Chernikov MV, Wikman G. Phytotherapy Research. 2004 jan;18(1):47–53. doi: 10.1002/ptr.1359. https://pubmed.ncbi.nlm.nih.gov/14750201/
A randomized controlled study of Kan Jang versus Amantadine in the treatment of influenza in Volgograd. Kulichenko LL, Kireyeva LV, Malyshkina EN, Wikman G. Journal of Herbal Pharmacotherapy. 2003;3(1):77–93. https://pubmed.ncbi.nlm.nih.gov/15277072/
A double blind, placebo-controlled study of Andrographis paniculata fixed combination Kan Jang in the treatment of acute upper respiratory tract infections including sinusitis. Gabrielian ES, Shukarian AK, Goukasova GI, Chandanian GL, Panossian AG, Wikman G, Wagner H. Phytomedicine. 2002 okt;9(7):589-97. doi: 10.1078/094471102321616391. https://pubmed.ncbi.nlm.nih.gov/12487322/
Double blind placebo-controlled pilot and Phase III study of a standardised Andrographis paniculata Herba Nees extract fixed combination (Kan jang) in the treatment of uncomplicated upper respiratory tract infection. Melchior J, Spasov AA, Ostrovskij OV, Bulanov AE, Wikman G. Phytomedicine. 2000 okt;7(5):341–50. doi: 10.1016/S0944-7113(00)80053-7. https://pubmed.ncbi.nlm.nih.gov/11081985/
Prevention of common colds with Andrographis paniculata dried extract. A pilot double blind trial. Cáceres DD, Hancke JL, Burgos RA, Wikman GK. Phytomedicine. 1997 Jun;4(2):101-4. doi: 10.1016/S0944-7113(97)80051-7. https://pubmed.ncbi.nlm.nih.gov/23195395/
Controlled clinicals study of standardized Andrographis paniculata extract in common cold – a pilot trial. Melchior J, Palm S, Wikman G. Phytomedicine. 1997 feb; 3(4):315-8. doi: 10.1016/S0944-7113(97)80002-5. https://pubmed.ncbi.nlm.nih.gov/23195187/
Use of visual analogue scale measurements (VAS) to assess the effectiveness of standardized Andrographis paniculata extract SHA-10 in reducing the symptoms of common cold. A randomized double-blind placebo study.Cáceres DD, Hancke JL, Burgos RA, Sandberg F, Wikman GK. Phytomedicine. 1999 okt;6(4):217-23. doi: 10.1016/S0944-7113(99)80012-9. https://pubmed.ncbi.nlm.nih.gov/10589439/
A double-blind study with a new monodrug Kan Jang: Decrease of symptoms and improvement in the recovery from common colds. Hancke JL, Burgos R, Cáceres DD, Wikman G. Phytotherapy Research. 1995;9(8):559–562. https://doi.org/10.1002/ptr.2650090804
(fatigue, feeling weak, stress, irritation, mild anxiety, recovery)
Studies show that recovery from illness and infections is accelerated, as well as stimulation of the body’s protective mechanisms. Well-being and coping are increased by strengthening the body mentally and/or physically when it is exposed to stress. Cognitive capacity and performance are improved.
Efficacy of Adaptogens in Patients with Long COVID-19: A Randomized, Quadruple-Blind, Placebo-Controlled Trial. Karosanidze I, Kiladze U, Kirtadze N, Giorgadze M, Amashukeli N, Parulava N, Iluridze N, Kikabidze N, Gudavadze N, Gelashvili L, Koberidze V, Gigashvili E, Jajanidze N, Latsabidze N, Mamageishvili N, Shengelia R, Hovhannisyan A, Panossian A. Pharmaceuticals 2022, 15, 345. https://doi.org/10.3390/ph45030
Efficacy of Adaptogenic Supplements on Adapting to Stress: A Randomized, Controlled Trial.
Hovhannisyan A, Nylander M, Wikman G, Panossian A. Journal of Athletic Enhancement. 2015, 4:4. doi:10.4172/2324-9080.1000205. http://dx.doi.org/10.4172/2324-9080.1000205
Adaptogens in Mental and Behavioral Disorders. Panossian AG. Psychiatr Clin North Am. 2013 Mar;36(1):49-64. doi: 10.1016/j.psc.2012.12.005. https://pubmed.ncbi.nlm.nih.gov/23538076/
Evaluation of molecular chaperons Hsp72 and neuropeptide Y as characteristic markers of adaptogenic activity of plant extracts. Asea A, Kaur P, Panossian A, Wikman GK. Phytomedicine. 2013 nov 15;20(14):1323-9. doi: 10.1016/j.phymed.2013.07.001. https://pubmed.ncbi.nlm.nih.gov/23920279/
Synergy and antagonism of active constituents of ADAPT-232 on transcriptional level of metabolic regulation of isolated neuroglial cells. Panossian A, Hamm R, Kadioglu O, Wikman G, Efferth T. Front Neurosci. 20 februari 2013; 7:16. doi: 10.3389/fnins.2013.00016. https://pubmed.ncbi.nlm.nih.gov/23430930/
Double-blind, placebo-controlled, randomised study of single dose effects of Adapt-232 on cognitive functions. Aslanyan G, Amroyan E, Gabrielyan E, Nylander M, Wikman G, Panossian A. Phytomedicine. 2010 Jun;17(7):494-9. doi: 10.1016/j.phymed.2010.02.005. Epub 2010 5 april. https://pubmed.ncbi.nlm.nih.gov/20374974/
Effects of adaptogens on the Central Nervous System and the Molecular Mechanisms associated with their stress-protective activity. Panossian A, Georg W. Pharmaceuticals (Basel). 2010 Jan; 3(1): 188–224. doi: 10.3390/ph3010188. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991026/
Impact of Chisan® (ADAPT-232) on the quality-of-life and its efficacy as an adjuvant in the treatment of acute non-specific pneumonia. Narimanian M, Badalyan M, Panosyan V, Gabrielyan E, Panossian A, Wikman G, Wagner H. Phytomedicine. 2005 Nov;12(10):723-9. doi: 10.1016/j.phymed.2004.11.004. https://pubmed.ncbi.nlm.nih.gov/16323290/
Evaluation of the effect of a single dose of a phytoadaptogen on the working capacity of human subjects during prolonged isolation. Bogatova RI, Shlykova LV, Salnitsky VP, Wikman G. Aerospace and Environmental Medicine (Aviakosm Ekolog Med). 1997;31(4):51–4. https://pubmed.ncbi.nlm.nih.gov/9424198/
Rhodiola rosea vs. sertraline for major depressive disorder: A randomized placebo-controlled trial. Mao JJ, Xie SX, Zee J, Soeller I, Li QS, Rockwell K, Amsterdam JD. Phytomedicine. 2015 Mar 15;22(3):394–9. doi: 10.1016/j.phymed.2015.01.010. https://pubmed.ncbi.nlm.nih.gov/25837277/
Vårt rosenrotsextrakt användes i studien.
Rhodiola rosea therapy for major depressive disorder: A study protocol for a randomized, double-blind, placebo-controlled trial. Mao JJ, Li QS, Soeller I, Xie SX, Amsterdam JD. Journal of Clinical Trials. 20 juni 2014; 4:170. doi: 10.4172/2167-0870.1000170. https://pubmed.ncbi.nlm.nih.gov/25610752/
Vårt rosenrotsextrakt användes i studien.
A randomised, double-blind, placebo-controlled, parallell-group study of the standardised extract SHR-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue. Olsson EMG, Von Schéele B, a. Panossian AG. Planta Med. 2009 feb;75(2):105-12. doi: 10.1055/s-0028-1088346. https://pubmed.ncbi.nlm.nih.gov/19016404/
Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression. Darbinyan V, Aslanyan G, Amroyan E, Gabrielyan E, Malmström C, Panossian A. Nordic Journal of Psychiatry. 2007;61(5):343–8. doi: 10.1080/08039480701643290. https://pubmed.ncbi.nlm.nih.gov/17990195/
A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Shevtsov VA, Zholus BI, Shervarly VI, Vol’skij VB, Korovin YP, Khristich MP, Roslyakova NA, Wikman G. Phytomedicine. 2003 Mar;10(2–3):95–105. doi: 10.1078/094471103321659780. https://pubmed.ncbi.nlm.nih.gov/12725561/
Rhodiola rosea in stress induced fatigue – A double blind cross-over study of a standardized extract SHA-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Darbinyan V, Kteyan A, Panossian A, Gabrielian E, Wikman G, Wagner H. Phytomedicine. 2000 okt;7(5):365–71. doi: 10.1016/S0944-7113(00)80055-0. https://pubmed.ncbi.nlm.nih.gov/11081987/
A double-blind placebo-controlled pilot study of the stimulating effect of Rhodiola rosea SHR-5 extract on the physical and mental work capacity of students during a stressful examination period with a repeated low-dose regimen. Spasov AA, Wikman GK, Mandrikov VB, Mironova IA, Neumoin VV. Phytomedicine. 2000 apr;7(2):85-9. doi: 10.1016/S0944-7113(00)80078-1. https://pubmed.ncbi.nlm.nih.gov/10839209/
(iron deficiency anemia, fatigue, iron deficiency, pale skin color, irritability, weakness, constipation, brittle nails, cold hands and feet, headache, low sense of well-being)
The study showed increased haemoglobin and serum iron levels as well as erythrocyte counts (red blood cells), reduced fatigue and increased well-being. Already after a week, better blood count was noted!
Comparative study of Femineral and Floradix in women of child-bearing age and adolescent girls with iron deficiency anaemia. Babayan S, Aslanyan G, Amroyan E, Gabrielyan E, Wikman G, Panossian. Scientia Pharmaceutica. 2008; 76; 725–742. https://www.mdpi.com/2218-0532/76/4/725
(mild worry, anxiety, GAD)
Studies showed a reduction in GAD symptoms. Chamomile contributes to a calm state of mind.
Long-term chamomile (Matricaria chamomilla L.) treatment for generalized anxiety disorder: A randomized clinical trial. Mao JJ, Xie SX, Keefe JR, Soeller I, Li QS, Amsterdam JD. Phytomedicine. 2016 Dec 15;23(14):1735-1742. doi: 10.1016/j.phymed.2016.10.012. https://pubmed.ncbi.nlm.nih.gov/27912875/
Vårt kamomillextrakt användes i studien.
Short-term open-label chamomile (Matricaria chamomilla L.) therapy of moderate to severe generalized anxiety disorder. Keefe JR, Mao JJ, Soeller I, Li QS, Amsterdam JD. Phytomedicine. 2016 Dec 15;23(14):1699-1705. doi: 10.1016/j.phymed.2016.10.013. https://pubmed.ncbi.nlm.nih.gov/27912871/
Vårt kamomillextrakt användes i studien.
